Normalization of testosterone level after testosterone replacement therapy could decrease risk of cardiovascular events and mortality in men.
Patients with low testosterone levels who have then gone on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke, according to research published today (Thursday) in the European Heart Journal.
In the study, researchers from Kansas City VA Medical Centre in Kansas City, USA, examined the effect of TRT on cardiovascular outcomes by comparing incidences of heart attack, stroke, and all-cause mortality among different sub-populations of treated and untreated patients. The study used the largest cohort of patients and the longest follow-up for TRT to date.
Data from 83,010 male veterans, all without history of myocardial infarction (MI) or stroke, who were treated between December 1999 and May 2014 was used to establish that only 63% of patients achieved normal testosterone levels after TRT More importantly, the group who had normalized testosterone levels after TRT had significantly fewer deaths and cardiovascular events than those who did not.